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Jardiance: The First Drug Shown to Help People with All Types of Heart Failure

Heart failure is one of the most common diabetes complications. New results from the EMPEROR-Preserved clinical trial show that Jardiance is one of the first medications shown to help all people with​ heart failure.

People with type 2 diabetes are 2-4 times more likely to experience heart failure, one of the most common diabetes complications. Heart failure occurs when your heart is not able to pump enough blood to the rest of your body and can refer to either right- or left-sided heart failure. Left-sided heart failure is more common and consists of both reduced and preserved ejection fractions: 

  1. Heart failure with reduced ejection fraction (HFrEF): HFrEF occurs when the heart muscle becomes weaker and only pumps out less than 50% of blood from its chambers.
  2. Heart failure with preserved ejection fraction (HFpEF): HFpEF usually occurs when the heart muscle becomes stiff, reducing the total amount of blood the heart can hold. However, the heart is still able to pump this reduced amount from its chambers.

While some diabetes medications have been shown to reduce your risk of developing HFrEF, the EMPEROR-Preserved trial is the first trial that was successful in showing positive benefits for both types of left-sided heart failure. Other trials, such as the DELIVER trial (investigating the effects of Farxiga on HFpEF) are underway to see if other SGLT-2 inhibitors can also protect against this condition.

EMPEROR-Reduced and EMPEROR-Preserved separately investigated the effect of the SGLT-2 inhibitor Jardiance (empagliflozin) on hospitalization and death due to both HFrEF and HFpEF respectively.

Results from the EMPEROR-Preserved trial, which included 5,988 participants with HFpEF both with and without type 2 diabetes, showed a reduced risk for hospitalization or cardiovascular death due to HFpEF. Specifically, Jardiance reduced the risk of hospitalization by 29%.

Jardiance was also shown to reduce the total number of hospitalizations due to heart failure, and it extended the time to a person’s first hospitalization compared to the placebo.

Earlier in 2021, the EMPEROR-Reduced trial, which included 3,730 people, both with and without type 2 diabetes, showed that Jardiance reduced the risk of heart failure by 25% compared to those receiving a placebo. The trial also showed that Jardiance reduced the risk of first and recurrent hospitalization for heart failure by 30% compared to the placebo. 

Jardiance was officially approved in 2021 by the FDA to treat heart failure with reduced ejection fraction (HFrEF) in people with and without diabetes. It was the first clinically proven medication to help people with both types of left-sided heart failure. 

Jardiance is the second SGLT-2 inhibitor approved to treat this condition, following Farxiga (dapagliflozin) in 2020. In February 2022, Jardiance was approved to reduce the risk of cardiovascular death and hospitalization for heart failure in all adults, regardless of diabetes status. The approval widens the population of people who can now use the drug and adds to the list of approved medications for heart failure – the leading cause of hospitalization for adults over 65.

In 2023, a new drug called Inpefa (sotagliflozin) – a combination of SGLT-1 and SGLT-2 inhibitors – was approved by the FDA for use in heart failure patients, regardless of their diabetes status and ejection fraction.

To learn more about heart failure and how it could impact you, check out diaTribe’s two-part series on the topic: