Type 2 Diabetes Clinical Trials
Advances in blood glucose management, weight loss, and kidney health are at the forefront of type 2 diabetes research. Here are several exciting type 2 diabetes trials that are actively recruiting.
Managing diabetes can be challenging, but researchers and volunteers around the world are working hard to achieve a brighter future for people with type 2 diabetes.
Clinical trials allow researchers to evaluate the safety and efficacy of new drugs and technologies. These trials would not be possible without the thousands of brave volunteers who participate each year.
Here are some exciting trials for people with type 2 diabetes that are actively recruiting.
New medication for obesity and weight-related conditions
The SYNCHRONIZE-CVOT study will investigate the cardiovascular safety of survodutide, a new once-weekly injection of a GLP-1 receptor agonist drug being developed for weight management.
Tirzepatide for chronic kidney disease
This study is investigating whether the dual GIP/GLP-1 agonist tirzepatide (sold as Mounjaro for type 2 diabetes and Zepbound for obesity) can help treat chronic kidney disease in people with obesity with or without type 2 diabetes.
Intestinal procedure for treatment of type 2 diabetes
A one-time outpatient intestinal procedure called duodenal mucosal resurfacing (DMR) is being studied in the REVITALIZE-1 trial to see if it can help people with type 2 diabetes improve their A1C and other diabetes-related measures. DMR has been approved in Europe but has not yet received FDA approval in the U.S.
Oral semaglutide for preteens and teens with type 2 diabetes
The PIONEER TEENS trial is studying the use of oral semaglutide in preteens and teens with type 2 diabetes. Semaglutide is FDA-approved for diabetes management (as Ozempic), weight management (as Wegovy), or to reduce cardiovascular events in adults with type 2 diabetes.
More clinical trials to watch out for:
New oral GLP-1 drug
- The ACHIEVE-5 study will test the safety and effectiveness of a new daily oral medication called orforglipron to treat type 2 diabetes.
Cell-based therapy to treat kidney disease
- This study is testing a new injectable treatment in people with type 2 diabetes and chronic kidney disease that's designed to regenerate and repair kidney tissue.
Weight management drug being tested for type 2 diabetes
- The TRANSCEND-T2D-2 study will investigate the safety and effectiveness of a medicine called retatrutide – a GIP/GLP-1/glucagon receptor tri-agonist – to improve blood sugar in people with type 2 diabetes.
Exercise vs. weight loss medication
- The REIMAGINE 1 clinical trial will study how the investigational medicine CagriSema (cagrilintide and semaglutide) helps improve blood sugar levels and reduce weight in people with type 2 diabetes compared to exercise alone.
Treatment for retinopathy
- This study will test the effectiveness of the medicine tarcocimab to treat non-proliferative diabetes-related retinopathy.
New use for cholesterol medicine
- Fenofibrate is an oral medicine used to lower high cholesterol and triglyceride (fatty acid) levels in the blood. This study will examine whether the drug is effective for preventing diabetic retinopathy.
Learn more about type 2 diabetes research and treatments: