Trial Tests New Drug Combo To Reduce Cardiovascular Risk in Type 2
If you have type 2 diabetes, high blood pressure, and cardiovascular disease without a history of heart failure, you may be eligible for a clinical trial testing whether a new investigational drug taken with Jardiance can reduce the risk of heart-related issues.
Trial Status: Recruiting
Clinical Trials Identifier: NCT07064473
Trial Name: Study to Test Vicadrostat Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
Diabetes Type: Type 2 diabetes
Trial Sponsor: Boehringer Ingelheim
Why is this study important?
People with type 2 diabetes have 2-4 times the risk of heart attack, stroke, and other cardiovascular events compared to those without diabetes.
The diabetes drug empagliflozin (Jardiance) is an SGLT-2 inhibitor, which improves blood sugar management by helping the kidneys to flush out excess glucose. Jardiance has also been shown to reduce cardiovascular risk. The study will add vicadrostat, an investigational medicine that blocks the enzyme the body uses to make aldosterone, a hormone that, under certain circumstances, can raise blood pressure, increase fluid retention, and contribute to cardiovascular and kidney damage.
How does the trial work?
Two groups will be randomly selected to receive either vicadrostat and empagliflozin and or vicadrostat and a placebo. Participants will receive follow-ups for up to four years, tracking any cardiovascular events and side effects.
Are you interested in participating?
You may be eligible if you:
- Have type 2 diabetes
- Are at least 18 years old
- Have a history of high blood pressure and are on active treatment
- Are receiving treatment for heart disease
- Have at least one additional risk factor for developing heart failure
- Are a woman of childbearing potential who can use birth control
People who have a history of heart failure are not eligible. See a full list of inclusion/exclusion criteria here. The trial is currently recruiting at over 1,100 locations around the world.
Learn more about heart health treatments here: