SGLT-2 Inhibitors

How do SGLT-2 inhibitors work to lower blood sugar

As our kidneys filter our blood, they also reabsorb glucose. SGLT-2 inhibitor drugs block the process of reabsorbing glucose back into our blood, causing glucose to be excreted through urine. Since extra glucose leaves the body instead of returning to the bloodstream, SGLT-2 inhibitors can lower the amount of sugar in the blood and, as a result, they can also lower A1C levels and body weight.

List of SGLT-2 inhibitor medications

Commonly medications in the SGLT-2 drug class include:

• Invokana (canaglifozin)
• Farxiga (dapaglifozin)
• Jardiance (empagliflozin)
• Steglatro (ertugliflozin)

Further reading about SGLT-2 inhibitor medications

SGLT-2s and their cardiovascular and kidney benefits

• Farxiga Shows Potential to Protect Millions of People with Chronic Kidney Disease
• Medications That Protect the Heart: New Data on SGLT-2s and GLP-1s
• Studies Suggest Diabetes Drugs Help Hearts and Kidneys for People With or Without Diabetes
• Great News: Trials Show Some Diabetes Drugs Can Actually Protect Your Kidneys
• What are SGLT-2 Inhibitors and How Can They Help Your Heart
• Invokana: Heart & Kidney Benefits, Same Safety Concerns on Amputation
• Jardiance: The First Diabetes Drug to Reduce Risk of Heart-Related Death
• SGLT-2 Inhibitor Jardiance Reduces Cardiovascular Events by 14% in High-Risk 

Taking SGLT-2 medications with type 1 diabetes

• Using SGLT-2 Inhibitors to Help Manage Type 1 Diabetes
• SGLT inhibitors for Type 1 Diabetes: What to Know
• Two Pills for Type 1 Diabetes Under US and European Review
• Can An Add-on Pill for Type 1 Diabetes Improve A1c and Weight Loss?