Eversense 365: How It Works, Features, Latest Updates
- The Eversense 365 is a CGM system for people with diabetes 18 and older, with an implantable sensor that only needs to be changed once a year.
- The system's removable transmitter uses an adhesive patch that's changed daily.
- The CGM is FDA-approved for use with Sequel's twiist automated insulin delivery system.
While most CGM sensors offer a wear time of 10 to 15 days, the Eversense 365 from Senseonics is the first CGM with a sensor that can be worn continuously for a full year. The FDA approved the Eversense 365 for use in the U.S. in 2024.
In 2022, Senseonics introduced the Eversense E3, which needs to be changed every 180 days. It is currently available in the U.S. and Europe.
What is the Eversense 365?
The Eversense 365 is an implantable CGM that provides up to 365 days of continuous glucose readings. The system's components include:
- An implantable sensor that must be inserted (and later removed) under the skin of the upper arm by a trained healthcare professional.
- A removable, rechargeable transmitter, placed right above the implanted sensor, that sends glucose readings via Bluetooth to a mobile phone app. It can be put on and removed by the user using a silicone-based adhesive designed to minimize skin reactions.
- An iPhone or Android mobile app, which shows users their glucose data and trends every five minutes and allows them to receive high and low alarms. The Eversense 365 offers vibration alerts to notify users when a mobile phone is out of reach.
Eversense 365 calibrations
Unlike the Eversense E3, which requires daily fingerstick calibration, the Eversense 365 requires four initial fingerstick calibrations (two to 12 hours apart), with readings appearing after the second calibration.
For the first 13 days, daily calibrations are required, followed by one fingerstick calibration per week. Additional calibrations are recommended if symptoms do not match CGM readings or if users are taking certain medications.
AID integration options for Eversense 365
The Eversense 365 is FDA-cleared as an integrated CGM (iCGM) system, meaning that it can operate with compatible medical devices like insulin pumps, as part of an automated insulin delivery system.
In early 2026, Eversense announced the CGM was widely available for the Sequel twiist AID system. The twiist also works with Abbott's FreeStyle Libre 3 Plus sensor.
Eversense 365 cost and availability
While coverage varies, most private insurers and Medicare cover a portion of the cost of the Eversense insertion and removal procedures, as well as that of the device itself.
Eversense offers a discount program that allows qualifying participants to receive a sensor, transmitter, and subsequent sensors for $199 per year.
Without insurance, the smart transmitter is estimated to cost around $1,000.
The bottom line
The new Eversense 365 offers a markedly different option than other CGM systems and represents a significant leap in diabetes tech innovation. Though a smaller number of people with diabetes use an Eversense CGM compared to other CGM devices, the convenience of a sensor that only needs to be replaced once a year could be a very attractive alternative for some.
While Eversense 365 requires a minor surgical procedure and fingerstick calibrations, potential advantages include fewer wasted sensors, less skin irritation, more discretion, and fewer compression lows compared to other CGM devices, which typically have 10- to 15-day wear times.
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