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Medtronic Simplera CGM: How It Works, Features, and Latest Updates

3 Minute Read
The Medtronic Simplera CGM shown with the InPen smart insulin pen.

Key takeaways: 

  • The Simplera is Medtronic's smallest continuous glucose monitor. It's disposable and has a flat, square shape.
  • There are two versions of the CGM: The Simplera works with the company's smart insulin pen (the InPen) and the Simplera Sync integrates with the MiniMed 780G AID system.
  • The latest: The FDA recently approved Medtronic’s Simplera Sync sensor for use with its MiniMed 780G system. The new sensor is fully disposable, requires no fingersticks, and streams glucose data directly to the pump without a separate transmitter. 

The FDA has approved Medtronic's Simplera Sync CGM, the company's first disposable continuous glucose monitor (CGM), which is half the size of its current sensor. 

Designed for people with diabetes aged 2 years and older, Simplera is a major upgrade from the Guardian 4 sensor. The device has a flat, square shape and does not require overtape. Simplera Sync was recently FDA-approved for use with the MiniMed 780G, with a limited U.S. launch planned for fall 2025. The Simplera CGM, which integrates with the InPen smart insulin system, was approved by the FDA in 2024.

The CGM's simple two-step insertion is similar to that of the Dexcom G7 and Freestyle Libre 3.  

Simplera features

Simplera is the first major redesign of a Medtronic CGM. Key features include: 

  • Smaller size: Simplera is smaller than the Guardian 4 sensor and has a flat shape. It is worn on the back of the upper arm.
  • No fingersticks: Simplera requires no fingerstick calibrations. After the two-hour warm-up period, you’re good to go.
  • Simple, two-step insertion process: The sensor itself is in the middle of the Simplera device (unlike the Guardian 4), making it easier to align for insertion.
  • All-in-one disposable device: Simplera is Medtronic’s first fully disposable CGM, with the sensor and transmitter combined into one device.
  • No overtape required: This means that the overall “footprint” of the device is much smaller than that of the Guardian 4. Simplera’s adhesive is made from an anti-lint material and is designed to prevent sweat and water from reaching the sensor. 

Medtronic also preserved some of the key features from the Guardian 4 for Simplera, including: 

  • Two-hour warm-up time
  • Seven-day lifespan: While this is shorter than other CGMs on the market, a seven-day lifespan can be helpful for those who like to have a regular routine, such as changing their sensor every Sunday morning.
  • InPen smart insulin pen integration: The InPen provides personalized dosing guidance for people on multiple daily injections of insulin through the InPen app. The app offers a bolus calculator based on carb ratios, meal estimations, the amount of insulin on board, and fixed dosing regimens. Together, the Simplera and InPen form Medtronic’s Smart MDI system.
  • Compatibility with Apple iOS and Android, including notifications on the Apple Watch. 

Learn more about the latest CGMs here: