Combination Drugs

How they work: Combination therapies put multiple drug classes into a single medication. Combinations can be injectable (i.e. GLP-1 agonists with basal insulin in a single injection) or “fixed-dose combination” tablets that can be taken orally (i.e.  metformin combined with an SGLT-2 inhibitor into a single pill). Typically, they are meant to improve efficacy and potentially reduce side effects compared to taking multiple drugs separately. It also increases convenience for patients and has the potential to decrease co-pays for multiple medications.

Approved Drugs:

• Janumet / Janumet XR (sitagliptin + metformin or metformin extended release)

• Kombiglyze XR (saxagliptin + metformin extended release)

• Jentadueto (linagliptin + metformin)

• Kazano (alogliptin + metformin)

• Oseni (alogliptin + pioglitazone)

• Invokamet (canagliflozin + metformin)

• Xultophy (insulin degludec + liraglutide)

• Xigduo XR (dapagliflozin + metformin extended release)

• Glyxambi (empagliflozin + linagliptin)

• Synjardy (empagliflozin + metformin)

• Soliqua (insulin glargine + lixisenatide)

• Steglujan (ertugliflozin + sitagliptin)

• Segluromet (ertugliflozin + metformin)

• Eucreas (vildagliptin + metformin)*

*Approved in Europe Only

Last updated: February 28, 2018