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SGLT-2 Inhibitors

How they work: SGLT-2 inhibitors are a new class of glucose-lowering drugs that cause the kidneys to excrete excess glucose through the urine; they are a unique drug class in that they work independently of insulin.

Who uses them: SGLT-2 inhibitors are currently only approved for type 2 diabetes, although there is preliminary evidence that they may be able to help patients with type 1 diabetes.

In-Depth Article: The SGLT-2 Inhibitor Classa detailed article on the history and function of the SGLT-2 inhibitor class of drugs, plus a section on liver health.

Approved Drugs:

Drugs in Development

 

Pros

Cons

  • Relatively low risk of hypoglycemia

  • Good efficacy/A1c reduction

  • Potential for combination with other drugs

  • Oral drug, no injections

  • Weight loss

  • Reductions in blood pressure

  • Other benefits

  • Cardioprotection (only proven for Jardiance)

 

  • Increased risk of genital fungal infections, especially for women

  • Can cause frequent urination

  • More expensive than sulfonylureas/metformin

  • Cannot be taken by patients with impaired kidney function