Diabetes Drug Ozempic Approved for Weight Loss
By Matthew Garza and Rhea Teng
Wegovy, a once-weekly injectable medication (semaglutide), has been approved by the FDA to treat obesity and excess weight – conditions that can lead to type 2 diabetes and prediabetes. This new treatment has led to significant weight loss in clinical trials; expected to be available in the US this month.
Obesity is a complicated and serious chronic condition that can lead to many other complications – including type 2 diabetes, prediabetes, and heart disease. As of 2018, almost half (42%) of adults in the US lived with obesity, defined as a body mass index (BMI) over 30 kg/m2. However, most people with obesity are undiagnosed, and less than 3% have been prescribed a medicine to help them manage their condition. Although obesity and excess weight can directly lead to type 2 diabetes and prediabetes, weight management can reduce that risk – preventing or delaying the onset of these diseases.
On June 4, the FDA approved Novo Nordisk’s Wegovy (generic name: semaglutide), a once-weekly injection for chronic weight management. Semaglutide, a GLP-1 receptor agonist drug, is also approved in the US to treat type 2 diabetes as a once-weekly injection (Ozempic) and as a tablet taken orally (Rybelsus). In addition to improving diabetes management, Ozempic and Rybelsus support heart health. Ozempic is specifically approved to reduce the risk of serious heart problems, including heart attacks, strokes, and heart-related deaths in adults with type 2 diabetes and heart disease. A clinical trial is currently investigating whether Ozempic can slow the progression of chronic kidney disease in people with type 2 diabetes. Talk to your healthcare professional if you have type 2 diabetes and are interested in the blood sugar, or heart-protective effects of this medication.
Wegovy is a slightly higher dose than Ozempic. Wegovy is now approved for people with obesity (BMI greater than 30 kg/m2) or excess weight (BMI greater than 27 kg/m2) who also have at least one other weight-related health condition, such as type 2 diabetes, high blood pressure, or high cholesterol. The drug is used in combination with a reduced calorie meal plan and increased physical activity to support weight loss.
Wegovy’s STEP 1 clinical trial, published in the New England Journal of Medicine, included 1,961 people with obesity or excess weight who did not have diabetes. The weight loss results were impressive:
People taking Wegovy (in addition to diet and physical activity changes) lost, on average, 14.9% of their body weight after about 16 months, compared to only 2.4% weight loss in participants using the meal plan and exercise regimen without Wegovy.
83.5% of people taking Wegovy were able to lose at least 5% of their body weight, achieved by only 31.1% of people not taking Wegovy.
Dr. Donna Ryan, a renowned obesity researcher from the Pennington Biomedical Research Center at LSU, said, “[This] is the best news I have [heard] in a long time, and I have been eagerly awaiting it.” And Dr. Robert Kushner from Northwestern University, who was an author on the research papers that led to Wegovy’s approval, said, “The approval of Wegovy provides the availability of a more effective medication for the management of obesity and sets the stage for a new generation of drugs that harness the benefits of naturally occurring hormones such as GLP-1.”
According to Novo Nordisk, Wegovy will be available to people with obesity and excess weight as soon as this month. The cost will vary depending on whether you have health insurance that covers the medication; not all health insurance covers obesity treatment. Some people without insurance may qualify for a $25 monthly copay assistance program.
By treating obesity and excess weight as chronic conditions, this could help prevent people from developing type 2 diabetes and other health complications. The new type of treatment may also help address the stigma around diabetes and obesity – neither condition is a lifestyle choice nor personal flaw, but rather the two are medical conditions involving a number of factors, including genetics and environment.